Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch
K. H. Gretarsson, S. Abini-Agbomson, S. Gloor, D. N. Weinberg, J. L. McCuiston, V. U. N. S. Kumary, A. Hickman, V. Sahu, R. Lee, X. Xu, N. Lipieta, S. Flashner, O. A. Adeleke, I. K. Popova, H. Taylor, , C. Lu
The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.
bioRxiv · Mar 18, 2024Cancer Biology