Author

S. Flashner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

H. Nakagawa· 3 shared A. J. Klein-Szanto· 2 shared M. Shimonosono· 2 shared N. Matsuura· 2 shared A. B. Muir· 1 shared A. Hickman· 1 shared A. S. Parikh· 1 shared A. Sowash· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

H. Nakagawa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids

M. Shimonosono, M. Morimoto, W. Hirose, Y. Tomita, N. Matsuura, S. Flashner, M. S. Ebadi, E. H. Okayasu, C. Y. Lee, W. R. Britton, C. Martin, B. R. Wuertz, A. S. Parikh, U. M. Sachdeva, F. G. Ondrey, , H. Nakagawa

This study optimizes ADF-based medium for normal human esophageal organoids and models pathological changes using inflammatory and pharmacological stimuli.

bioRxiv · May 20, 2024Cell Biology

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch

K. H. Gretarsson, S. Abini-Agbomson, S. Gloor, D. N. Weinberg, J. L. McCuiston, V. U. N. S. Kumary, A. Hickman, V. Sahu, R. Lee, X. Xu, N. Lipieta, S. Flashner, O. A. Adeleke, I. K. Popova, H. Taylor, , C. Lu

The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.

bioRxiv · Mar 18, 2024Cancer Biology

ALDH2 dysfunction accelerates ESCC pathogenesis

S. Flashner, M. Shimonosono, N. Matsuura, S. Ohashi, A. J. Klein-Szanto, J. A. Diehl, C.-H. Chen, H. Nakagawa

This study shows that ALDH2 dysfunction accelerates ESCC pathogenesis by increasing CSCs, ROS, and DNA damage, and reduces response to cisplatin chemotherapy.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

Transcription factor Sp1 regulates mitotic fidelity through Aurora B kinase-mediated condensin I localization

S. Flashner, M. Swift, A. Sowash, J. Azizkhan-Clifford

This study shows Sp1 regulates mitotic fidelity by controlling Aurora B kinase and condensin I localization, with implications for cancer aneuploidy.

bioRxiv · Jun 19, 2020Cell Biology