R. Lee

Development and Utilization of 3D Anatomy Education Content using Metaverse and XR for Remote Telemedicine Education

This study develops a Metaverse-based anatomy education platform using AR HMD and XR technologies to enhance remote medical training.

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch

The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.

A Modified BPaL Regimen for Tuberculosis Treatment replaces Linezolid with Inhaled Spectinamides

This paper evaluates a modified BPaL regimen replacing linezolid with inhaled spectinamide 1599 for tuberculosis treatment, showing similar efficacy while avoiding linezolid-associated adverse events.

The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

The paper identifies CBR-5884 as a potent inhibitor of Candida albicans Cho1, showing fungistatic effects and disrupting in vivo Cho1 function.

Understanding the heterogeneity of alloreactive natural killer cell function inkidney transplantation

This study identifies NK cell subpopulations and their functional responses in kidney transplant patients, linking pre-transplant NK cell characteristics to long-term graft function.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

Identifying Membrane Protein-Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry

This paper introduces a method to identify lipid-protein interactions using lipidomic lipid exchange-mass spectrometry and applies it to study three membrane proteins.

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

Delayed development of basal spikelets in wheat explains their increased floret abortion and rudimentary nature

This study identifies delayed development and reduced developmental age of basal florets in wheat as the cause of their abortion and rudimentary nature, challenging the assimilate availability hypothesis.

Angie-LAMP for diagnosis of human eosinophilic meningitis using dog as proxy: A LAMP assay for Angiostrongylus cantonensis DNA in cerebrospinal fluid

This paper develops a LAMP assay (Angie-LAMP) for detecting Angiostrongylus cantonensis DNA in canine cerebrospinal fluid, showing comparable sensitivity to qPCR and improved portability for field use.

Diversity, Equity, and Inclusion in the Melanoma Research Community

The paper assesses diversity, equity, and inclusion in the melanoma research community through an international survey, revealing significant inequities related to gender, ethnicity, and geography.

Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles

The paper designs peptide-based sensors using machine learning and OBPs to detect VOCs in exhaled breath for disease monitoring.

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

This paper identifies enoxolone, a licorice metabolite, as an inhibitor of C. difficile toxin production by disrupting metabolic pathways, showing improved efficacy when combined with vancomycin in a mouse model.

Deep Learning-based Automated Rare Sperm Identification from Testes Biopsies

The paper develops a CNN to detect rare sperm in testis biopsies, achieving an 85.2% F1 score, which could improve IVF-ICSI success rates for NOA patients.

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

Safety and efficacy of a new vaginal gel, Feminilove, for the treatment of symptoms associated with vaginal dryness and vulvovaginal atrophy in women: an in vitro and in vivo study

PROTECTIVE ROLE FOR SMOOTH MUSCLE CELL HEPCIDIN IN ABDOMINAL AORTIC ANEURYSM

This study shows that HAMP produced by smooth muscle cells protects against abdominal aortic aneurysm by suppressing LCN2.

Stepwise maturation of the peptidyl transferase region of human mitoribosomes

The paper identifies key assembly factors and their roles in the maturation of the peptidyl transferase region in human mitoribosomes.

Development of a Novel Index to Characterise Arterial Dynamics Using Ultrasound Imaging

The paper develops a brachial artery relaxation index (BARI) to predict abdominal aortic aneurysm (AAA) growth but finds no significant correlation between BARI and future AAA growth.

Single-cell analysis of developing B cells reveals dynamic gene expression networks that govern B cell development and transformation

The paper uses single-cell transcriptomics and proteomics to study B cell development, identifying novel proliferative phases and dynamic gene expression patterns linked to B cell transformation.

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

Liver-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

This study shows that liver-specific ANGPTL4 suppression improves obesity-related diabetes and reduces atherosclerosis in mice by enhancing lipid metabolism and reducing inflammation.

SARS-CoV2 Testing: The Limit of Detection Matters

This study evaluates how the limit of detection (LoD) of SARS-CoV-2 assays affects false negative rates using 27,500 test results, finding a 13% increase in false negatives per 10-fold LoD increase.

Anaerobic sulfur oxidation underlies adaptation of a chemosynthetic symbiont to oxic-anoxic interfaces

This study investigates how oxygen affects the physiology and metabolism of Candidatus Thiosymbion oneisti, an ectosymbiont of marine nematodes, revealing that sulfur oxidation genes are upregulated under anoxia.

Sequestration of Methane by Symbiotic Deep-Sea Annelids: Ancient and Future Implications of Redefining the Seep Influence

The paper identifies new deep-sea annelid-bacterial symbioses that actively consume methane, expanding the known spatial extent of methane seeps and their ecological impact.

Geldanamycin inhibits Jumonji histone lysine demethylase KDM4 and targets chimeric transcription factor PAX3-FOXO1

This study identifies geldanamycin and its analog 17-DMAG as dual KDM/Hsp90 inhibitors effective against PAX3-FOXO1-driven rhabdomyosarcoma.

Loss of MLKL Decreases Necrotic Core but Increases Macrophage Lipid Accumulation In Atherosclerosis

This study shows that reducing MLKL in atherosclerosis decreases necrotic cores but increases macrophage lipid accumulation, revealing a novel role for MLKL in lipid uptake.