C. Lu

Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering

This study screens all human paralog pairs to identify synthetic lethal interactions and finds that their strength depends on shared protein interaction networks and cellular context.

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

Discovery of cyclic peptide natural product inhibitors of Balamuthia mandrillaris

This study evaluates cyclic peptides as inhibitors of Balamuthia mandrillaris, finding eight compounds with IC50 <5 μM and minimal cytotoxicity.

HNF&alpha is a target of the Wnt/beta-catenin pathway and regulates colorectal carcinogenesis

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch

The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.

Architecture of the spinach plastid-encoded RNA polymerase

This study presents the cryo-EM structure of the spinach plastid-encoded RNA polymerase complex, revealing its composition and spatial arrangement of subunits and associated proteins.

Determination and characterization of papillomaviurs and parvovirus causing mass mortality of Chinese tongue sole (Cynoglossus semilaevis) in China

This study identifies two novel viruses, CsPaV and CsPV, as the causative agents of mass mortality in farmed Chinese tongue sole, revealing their co-infection and potential for further research on viral interactions.

Exploratory study of pulsed electric field ablation on atherosclerotic plaque in a rabbit model

This study investigates pulsed electric field ablation's effects on atherosclerotic plaques in rabbits, finding reduced lipid deposition, vascular remodeling, and increased elasticity.

Changes in physicochemical properties and microbial community succession during leaf stacking fermentation

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

The paper screens 140 chlamydial antigens in mice to find subunit vaccine candidates, finding none effective but identifying pathogenic antigens and showing viable organisms induce better immunity.

Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

EMDiffuse: a diffusion-based deep learning method augmenting ultrastructural imaging and volume electron microscopy

EMDiffuse enhances volume electron microscopy by using diffusion models to improve resolution and enable isotropic reconstruction of large biological volumes.

Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker

This study identifies αvβ5 integrin as a marker for activated tumor-resident Tregs in PDAC, showing that targeting it enhances immune checkpoint therapy.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

The paper identifies immune hubs in lung cancer that are associated with better responses to PD-1-blockade immunotherapy and contain stem-like CD8 T cells.

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

Heterotrophic bacteria drive sulfide oxidation in coastal sediments

This study identifies heterotrophic bacteria as key drivers of sulfur oxidation in coastal sediments and seawater by analyzing microbial communities and metagenomes.

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Exploring the genome and protein space of viruses

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

Conformational change of the Plasmodium TRAP I domain is essential for sporozoite migration and transmission of malaria

This study shows that conformational changes in the Plasmodium TRAP I-domain are essential for sporozoite gliding, salivary gland entry, and malaria transmission.

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancers

The paper introduces MaGIC, a ctDNA profiling method that improves cancer classification and chemosensitivity prediction by reducing background noise from cfDNA.

TCGADEPMAP -- Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas

TCGADEPMAP maps translational tumor dependencies and synthetic lethality using TCGA data, identifying novel targets like PAPSS1/2 with clinical implications.