Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation
C. A. Kulicke, G. M. Swarbrick, N. A. Ladd, M. Cansler, M. Null, A. Worley, C. Lemon, T. Ahmed, J. Bennett, T. N. Lust, C. M. Heisler, M. E. Huber, J. R. Krawic, L. M. Ankley, S. K. McBride, , M. J. Harriff
The paper demonstrates that delivering MR1 monomers loaded with 5-OP-RU enables ligand exchange to host MR1, leading to MR1T cell activation.
bioRxiv · Jul 11, 2022Immunology