Author

C. Limouse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Y. Chiang· 2 shared D. R. Alessi· 2 shared E. Purlyte· 2 shared H. S. Dhekne· 2 shared S. R. Pfeffer· 2 shared A. Adhikari· 1 shared E. G. Vides· 1 shared E. Jaimon· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

C. Y. Chiang

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2 papers

Recent·Most cited

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

H. S. Dhekne, F. Tonelli, W. M. Yeshaw, C. Y. Chiang, C. Limouse, E. Jaimon, E. Purlyte, D. R. Alessi, S. R. Pfeffer

The paper identifies Rab12 as a critical activator of pathogenic LRRK2 kinase through a CRISPR-based screen and structural analysis.

bioRxiv · Feb 17, 2023Biochemistry

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

E. G. Vides, A. Adhikari, C. Y. Chiang, P. Lis, E. Purlyte, C. Limouse, J. L. Shumate, E. S. Lasso, H. S. Dhekne, D. R. Alessi, S. R. Pfeffer

This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.

bioRxiv · Apr 25, 2022Biochemistry