The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.
C. Zavala-Alvarado, S. Garcia Huete, A. T. Vincent, O. Sismeiro, R. Legendre, H. Varet, G. Bussotti, C. Lorioux, P. Lechat, J.-Y. Coppee, F. J. Veyrier, M. Picardeau, N. Benaroudj
This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.
bioRxiv · Nov 6, 2020Microbiology