R. Legendre

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

This study profiles the transcriptome of human colonic cells exposed to SGG, showing it induces stronger transcriptional changes in cancerous HT29 cells than in normal FHC cells, with significant ER stress and UPR activation.

This study shows Leishmania amazonensis suppresses macrophage-regulated cell death pathways to promote chronic infection in vitro and in vivo.

This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

This study shows that larval exposure to specific bacteria in mosquitoes alters lipid metabolism, affecting adult survival and fitness.

This study examines how maternal age impacts gene expression in equine Day 8 embryos, identifying differences in mitochondrial and metabolic pathways in both trophoblast and inner cell mass.

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

This study characterizes the CovR regulatory network in Group B Streptococcus, showing its role in virulence gene regulation and strain-specific adaptations.

This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.

This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.

The paper identifies two distinct bladder macrophage subsets, shows their differential responses to infection, and demonstrates their impact on immune outcomes.

This study identifies the adaptive transcriptional response of Leptospira to peroxide stress, revealing key defense mechanisms against oxidative stress during infection.

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

This study identifies genes in Mycobacterium abscessus that enhance survival in macrophages by analyzing transcriptomes in amoebae and macrophages.