O. Sismeiro

Coordinated regulation of osmotic imbalance by c-di-AMP shapes beta-lactam tolerance in Group B Streptococcus

This study identifies c-di-AMP's role in beta-lactam tolerance in Group B Streptococcus by coordinating osmotic regulation and cell envelope stress responses.

MAPPING CHANGES OF MIRNA-MRNA NETWORKS IN LEISHMANIA-INFECTED MACROPHAGES PREDICTS REGULATORY MIRNA-TF LOOPS AS NOVEL TARGETS OF PARASITE IMMUNE SUBVERSION

Signal-independent activation reveals two-component regulatory networks

This study identifies two-component regulatory networks in Streptococcus agalactiae by activating histidine kinases to reveal connections between regulatory systems and their roles in pathogenicity and cell envelope homeostasis.

Transcriptome profiling of human colonic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.

This study profiles the transcriptome of human colonic cells exposed to SGG, showing it induces stronger transcriptional changes in cancerous HT29 cells than in normal FHC cells, with significant ER stress and UPR activation.

Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation

This study identifies bile as a trigger for biofilm formation in Bacteroides thetaiotaomicron and shows that extracellular DNA degradation by DNase BT3563 is essential for this process.

Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness

This study shows that larval exposure to specific bacteria in mosquitoes alters lipid metabolism, affecting adult survival and fitness.

The CovR regulatory network drives the evolution of Group B Streptococcus virulence

This study characterizes the CovR regulatory network in Group B Streptococcus, showing its role in virulence gene regulation and strain-specific adaptations.

Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides.

The paper shows indole, induced by sublethal tobramycin, increases persistence to aminoglycosides in V. cholerae via RaiA-mediated ribosome storage.

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.

This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.

The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress

This study identifies the adaptive transcriptional response of Leptospira to peroxide stress, revealing key defense mechanisms against oxidative stress during infection.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae.

This study shows that ribosomal protein gene location affects bacterial growth rate and macromolecular crowding in Vibrio cholerae.

Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages

This study identifies genes in Mycobacterium abscessus that enhance survival in macrophages by analyzing transcriptomes in amoebae and macrophages.