G. Bussotti

Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage

This study identifies oxidative DNA damage signatures in Leishmania donovani during sand fly infection, linking them to allelic and haplotype selection through genomic analysis.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

This study shows HPV integration disrupts host gene expression by altering 3D chromatin interactions, revealing a mechanism for early cervical cancer development.

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.

This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.

The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress

This study identifies the adaptive transcriptional response of Leptospira to peroxide stress, revealing key defense mechanisms against oxidative stress during infection.

Leishmania targets the macrophage epigenome and dampens the NF-κB/NLRP3- mediated inflammatory response

This study shows Leishmania amazonensis modulates macrophage epigenetics to suppress NF-κB and NLRP3 inflammasome activation, aiding parasite survival.