The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC
A. Legrand, C. Dahoui, C. De La Myre Mory, C. Loyer, K. Noy, L. Guiguettaz, M. Pillon, M. Wcislo, L. Gueguen, A. Cimarelli, M. Mateo, F. Fiorini, E. Ricci, L. Etienne
This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.
bioRxiv · Jan 19, 2023Immunology