A. Legrand

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

MORC2 restriction factor silences HIV proviral expression

This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.

The actin depolymerizing factor StADF2 alters StREM1.3 plasma membrane nanodomains to inhibit the Potato Virus X

This study shows that StADF2 alters StREM1.3 plasma membrane nanodomains to inhibit PVX cell-to-cell movement through REMORIN-dependent mechanisms.

The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.

CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules

This paper introduces CoVAMPnet, a framework to analyze how drug candidates affect disordered biomolecules, finding that TMP and SPA preserve structured conformations of Aβ42.

Driving forces behind remorin nanodomain formation in anionic lipid membranes

The paper investigates how phosphorylation of the N-terminal IDD in REM1.3 influences remorin clustering into lipid nanodomains in anionic model membranes.