A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
M. Maes, Z. A. Dyson, S. E. Smith, D. A. Goulding, C. Ludden, S. Baker, P. Kellam, S. T. Reece, G. Dougan, J. Bartholdson Scott
This study uses high-content imaging to screen a monoclonal antibody against E. coli ST131 isolates, identifying four binding phenotypes and linking them to genetic variations affecting O-antigen structure.
bioRxiv · May 22, 2020Microbiology