P. Kellam

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

The paper characterizes the immune repertoire of a humanised transgenic mouse using immunophenotyping and high-throughput sequencing, showing similarities to human BCR repertoires.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131

This study uses high-content imaging to screen a monoclonal antibody against E. coli ST131 isolates, identifying four binding phenotypes and linking them to genetic variations affecting O-antigen structure.

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

This study shows that IFI44 and IFI44L restrict RSV replication and are anti-viral and anti-proliferative, with IFI44L serving as a diagnostic marker for viral infection.

Comparative analysis reveals adaptive evolution of bat IFITMs and a novel antiviral determinant

The paper identifies adaptive evolution in bat IFITMs and a novel antiviral determinant involving S-palmitoylation at codon 70 and cysteine residues.

Development and use of Lentiviral Vectors Pseudotyped with Influenza B Haemagglutinins: application to vaccine immunogenicity, mAb potency and sero-surveillance studies

The paper develops influenza B haemagglutinin-pseudotyped lentiviral vectors as sensitive tools for detecting neutralizing and cross-reactive antibodies in vaccine and sero-surveillance studies.

Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing

This study uses next-generation sequencing to determine the mutation bias caused by favipiravir in influenza virus RNA, showing it primarily acts as a guanine analogue and secondarily as an adenine analogue.