Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging
N. J. Haywood, K. Bridge, C. Luk, N. Warmke, K. Simmons, M. Drozd, A. Moron, S. Straw, J. Scragg, J. Smith, S. Limumpornpetch, C. Ozber, C. Wilkinson, A. Skromna, N. Makava, , M. Kearney
This study shows that reducing endothelial IGF-1R in nutrient excess promotes white adipocyte beiging, increases energy expenditure, and improves insulin sensitivity through paracrine malonic acid release.
bioRxiv · Dec 1, 2021 · PreprintCell Biology