ImmunologybioRxiv
Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes
H. Kim, J. Perovanovic, A. Shakya…·D. Tantin
This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.
DOI 10.1084/jem.20200533