Author

D. Tantin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Ibarra· 2 shared A. R. Syage· 2 shared E. P. Hughes· 2 shared H. Kim· 2 shared J. Perovanovic· 2 shared W. Sun· 2 shared A. Poeschla· 1 shared A. Shakya· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. Ibarra

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors

W. Sun, E. P. Hughes, H. Kim, J. Perovanovic, K. R. Charley, B. Perkins, J. Du, A. Ibarra, A. R. Syage, J. S. Hale, M. A. Williams, D. Tantin

This study shows that OCA-B expression promotes CD4+ T cell memory and identifies memory precursor cells using a reporter mouse line.

Proceedings of the National Academy of Sciences · Feb 27, 2024Peer-reviewedImmunology

OCA-B promotes pathogenic maturation 1 of stem-like CD4+ T cells and autoimmune demyelination

E. P. Hughes, A. R. Syage, E. M. Mehrabad, T. E. Lane, B. T. Spike, D. Tantin

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

bioRxiv · Nov 29, 2023Immunology

GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia

M. E. Engel, W. Sun, J. Guo, D. McClellan, A. Poeschla, D. Bareyan, M. J. Casey, B. R. Cairns, D. Tantin

The paper identifies a non-canonical transcriptional mechanism in T-ALL where GFI1 and IKAROS cooperate to transactivate NOTCH3, independent of LSD1 binding.

bioRxiv · Mar 8, 2021Biochemistry

Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type-1 diabetes

H. Kim, J. Perovanovic, A. Shakya, Z. Shen, C. N. German, A. Ibarra, J. L. Jafek, N.-P. Lin, B. D. Evavold, D. H.- C. Chou, P. E. Jensen, X. He, D. Tantin

This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.

bioRxiv · Feb 6, 2020Immunology

Oct1/Pou2f1 is selectively required for gut regeneration and regulates gut malignancy

K. Vazquez-Arreguin, C. Bensard, J. C. Schell, E. Swanson, X. Chen, J. Rutter, D. Tantin

This study shows Oct1/Pou2f1 is essential for gut regeneration but has opposing roles in colon cancer depending on the tumor model.

bioRxiv · Sep 11, 2018Cancer Biology