Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment.
V. Jennings, R. Rumbold-Hall, G. Migneco, T. Barr, K. Reilly, N. Ingram, I. St Hilare, S. Heaton, N. Alzamel, D. Jackson, C. Ralph, I. McNeish, J. C. Bell, A. Melcher, C. S. Ilkow, , F. Errington-Mais
This study uses oncolytic viruses to deliver miRNA to TAMs, reversing their immunosuppressive activity and improving ovarian cancer immunotherapy efficacy.
bioRxiv · Jun 7, 2024 · PreprintCancer Biology