Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors
M. Yuan, C. G. Eberhart, C. A. Pratilas, J. O. Blakeley, C. Davis, M. Stojanova, K. Reilly, A. K. Meeker, C. M. Heaphy, F. J. Rodriguez
This study shows that combining NF1 and ATRX deficiency makes certain solid tumors vulnerable to ATR inhibition, especially those with alternative lengthening of telomeres.
bioRxiv · Feb 3, 2022 · PreprintCancer Biology