Author

J. C. Bell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Tanese De Souza· 2 shared M. J. F. Crupi· 2 shared T. Azad· 2 shared A. Buchler· 1 shared A. D'Souza· 1 shared A. Hagerman· 1 shared A. MacLean· 1 shared A. Pelin· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

C. Tanese De Souza

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

J. C. Bell, C. C. Dombrowski, J. L. Plank, R. B. Jensen, S. C. Kowalczykowski

This study uses single-molecule techniques to show BRCA2 chaperones RAD51 to RPA-coated ssDNA, overcoming kinetic barriers to promote homologous recombination.

bioRxiv · Dec 28, 2022 · PreprintBiochemistry

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway.

J. Hodgins, J. Abou-Hamad, A. Hagerman, E. Yakubovich, C. Tanese De Souza, M. Marotel, A. Buchler, S. Fadel, M. Park, C. Fong-McMaster, M. J. F. Crupi, J. C. Bell, M.-E. Harper, B. Rotstein, R. Auer, , M. Ardolino

PD-L1 promotes oncolytic virus infection by inhibiting the type I interferon pathway through a metabolic shift involving enhanced glycolysis and lactate production.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Plant-based expression of SARS-CoV-2 antigens for use in an oral vaccine

M. Power, T. Azad, J. C. Bell, A. MacLean

The paper evaluates the expression of SARS-CoV-2 RBD in edible plants to identify a candidate for an oral vaccine, finding lettuce as a suitable host.

bioRxiv · Dec 7, 2021Plant Biology

Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

O. Vermesh, A. D'Souza, I. S. Alam, M. Wardak, T. McLaughlin, F. El Rami, A. Sathirachinda, J. C. Bell, M. L. James, S. S. Hori, E. R. Gross, S. S. Gambhir

This paper develops a breath-based cancer detection system using engineered D-limonene production in tumors, achieving high sensitivity and specificity in mice and predicting human tumor detection limits.

bioRxiv · Sep 1, 2021 · PreprintBioengineering

Characterization of Critical Determinants of ACE2-RBD Interaction

E. E. F. Brown, R. Rezaei, T. Jamieson, J. Dave, N. T. Martin, R. Singaravelu, M. J. F. Crupi, S. Boulton, S. Tucker, J. Duong, J. Poutou, A. Pelin, H. Yasavoli-Sharahi, Z. Taha, R. Arulanandam, , T. Azad

This study identifies critical amino acid residues in SARS-CoV-2 RBD and ACE2 that influence binding affinity and neutralization by antibodies and inhibitors.

bioRxiv · Jan 29, 2021 · PreprintMicrobiology

An easily adopted murine model of distal pancreatectomy for investigating immunotherapy efficacy in resectable pancreatic adenocarcinoma

K. E. Baxter, C. Tanese de Souza, L.-H. Tai, P. Yaghini, M. Daneshmand, J. C. Bell, B. D. Lichty, M. A. Kennedy, R. C. Auer

This paper develops a surgically resectable murine model of pancreatic adenocarcinoma to test immunotherapy efficacy in preclinical studies.

bioRxiv · Mar 17, 2020 · PreprintCancer Biology