Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback
R. Bulkescher, T. Fleming, C. Rodemer, R. Medert, M. Freichel, M. P. Mayer, J. Szendroedi, S. Herzig, J. Zemva
This study shows that knocking out HSPA1A/HSPA1B in mouse endothelial cells leads to increased mitochondrial biogenesis and chaperone expression under methylglyoxal stress.
bioRxiv · Nov 30, 2021 · PreprintCell Biology