Author

M. P. Mayer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Mashaghi· 1 shared B. Niesler· 1 shared C. A. Beretta· 1 shared C. P. Sanchez· 1 shared C. Rodemer· 1 shared C. S. Simon· 1 shared C. Thiel· 1 shared E. J. Koers· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperBiophysics

A. Mashaghi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback

R. Bulkescher, T. Fleming, C. Rodemer, R. Medert, M. Freichel, M. P. Mayer, J. Szendroedi, S. Herzig, J. Zemva

This study shows that knocking out HSPA1A/HSPA1B in mouse endothelial cells leads to increased mitochondrial biogenesis and chaperone expression under methylglyoxal stress.

bioRxiv · Nov 30, 2021 · PreprintCell Biology

Direct observation of Hsp90-induced compaction in a protein chain

A. Mashaghi, F. Moayed, E. J. Koers, G. Kramer, M. P. Mayer, S. J. Tans

This study uses optical tweezers to show Hsp90 induces local contractions in unfolded protein chains, leading to global compaction and suppression of misfolding and aggregation.

bioRxiv · Aug 8, 2021Biophysics

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

M. Diehl, S. Weber, M. Cyrklaff, C. P. Sanchez, C. A. Beretta, L. Roling, C. S. Simon, J. Guizetti, M. P. Mayer, J. M. Przyborski

This study shows that the malaria parasite protein PFA66, a J-domain protein, works with host-derived HSP70 to facilitate knob biogenesis and cytoadherence in infected erythrocytes.

bioRxiv · Mar 11, 2021Cell Biology

Hsf1 is SUMOylated in the activated trimeric state

S. W. Kmiecik, K. Drzewicka, F. Melchior, M. P. Mayer

This study investigates how SUMOylation affects Hsf1 activity in vitro, finding that SUMOylation occurs in the activated trimeric state of Hsf1.

bioRxiv · Oct 5, 2020Biochemistry

Targeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation

R. Sakson, L. Beedgen, P. Bernhard, K. M. Alp, N. Luebbehusen, R. Roeth, B. Niesler, M. P. Mayer, C. Thiel, T. Ruppert

This study develops a targeted proteomics assay to quantify low-abundance glycosyltransferases in CDG patients, revealing specific protein level changes in ALG1 and ALG2 mutants.

bioRxiv · Sep 15, 2020Biochemistry

Breaking the Deadlock of Molecular Chaperones

T. Moran Luengo, R. Kityk, M. P. Mayer, S. G. D. Rudiger

This paper proposes a mechanism where Hsp70 and Hsp90 chaperones facilitate protein folding by creating a hydrophobicity gradient, allowing productive folding to occur.

bioRxiv · Aug 16, 2017Biochemistry