Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugation
T. Lehmann, H. Schneider, J. Tonillo, J. Schanz, D. Schwarz, C. Schroeter, H. Kolmar, S. Hecht, J. Anderl, N. Rasche, M. Rieker, S. Dickgiesser
The paper describes a modular method to generate PROxAb Shuttles by conjugating PROTAC-binding VHHs to antibodies, enabling targeted protein degradation and bispecific antibody creation.
bioRxiv · Mar 15, 2024Biochemistry