T. Lehmann

Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugation

The paper describes a modular method to generate PROxAb Shuttles by conjugating PROTAC-binding VHHs to antibodies, enabling targeted protein degradation and bispecific antibody creation.

Diversity, composition, altitude, and seasonality of high-altitude windborne migrating mosquitoes in the Sahel: Implications for disease transmission

The paper identifies high-altitude windborne mosquito migration in the Sahel, showing its role in disease transmission and highlighting key pathogens transported by these mosquitoes.

The African mosquito-borne diseasosome: Geographical patterns and range expansion

The paper maps the geographical patterns of mosquito-borne diseases in Africa, identifying key pathogens and vectors, and highlights risks for disease emergence.

Evaluating the contribution of aestivation to the persistence of malaria mosquitoes through the Sahelian dry season using stable isotopes

The paper uses stable isotopes to estimate the contribution of aestivation to the persistence of Anopheles coluzzii mosquitoes during the Sahelian dry season, finding that aestivation contributes at least 20% of the adult population.

Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows

CAMPI evaluates metaproteomic workflows across labs, finding sample processing drives peptide variability while workflows yield similar functional profiles.

Phenotyping in the era of genomics: MaTrics a digital character matrix to document mammalian phenotypic traits coded numerically

MaTrics provides a digital matrix of mammalian phenotypes linked to genomes, highlighting knowledge gaps and enabling genomic-phenomic comparisons.

Perturbations of the AMI1 IAM-amidohydrolase expression trigger plant stress responses in Arabidopsis thaliana

This study shows that AMI1, an IAM amidohydrolase, converts IAM to IAA and its repression under osmotic stress triggers ABA biosynthesis, linking auxin homeostasis to plant stress responses.

A novel fluorescence and DNA combination for complex, long-term marking of mosquitoes

This paper introduces a novel marking method for mosquitoes using fluorescent dye and synthetic DNA tags, showing long-term retention and no impact on survival or reproduction.

The effects of high-altitude windborne migration on survival, oviposition and blood-feeding of the African malaria mosquito, Anopheles gambiae s.l.

This study shows that Anopheles gambiae s.l. mosquitoes survive, oviposit, and blood feed after high-altitude flight, supporting their viability as vectors despite harsh conditions.

Induction of long-lived potential aestivation states in laboratory An. gambiae mosquitoes

This study induces long-lived aestivation-like states in laboratory Anopheles gambiae mosquitoes by manipulating environmental conditions to extend survival beyond typical lifespan.

Quantifying flight aptitude variation in wild A. gambiae s.l. in order to identify long-distance migrants

The paper quantifies flight aptitude variation in wild Anopheles gambiae s.l. mosquitoes to identify long-distance migrants, finding bi-modal distributions and seasonal increases in flight activity.

Massive windborne migration of Sahelian insects: Diversity, seasonality, altitude, and direction

The paper investigates windborne insect migration in the Sahel, finding large-scale movements across seasons, altitudes, and directions, with implications for ecosystem dynamics.

Variation in tolerance to parasites in natural Asian tiger mosquito populations and its effect on vectorial capacity

This study measures resistance and tolerance to dog heartworm in Asian tiger mosquito populations and finds that high transmission areas show increased tolerance, which enhances vectorial capacity.