Author

C. Sotriffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. Doelle· 1 shared A. Kraemer· 1 shared B. Adhikari· 1 shared B. Kuester· 1 shared C. Arrowsmith· 1 shared C. Wiedemann· 1 shared D. Barsyte-Lovejoy· 1 shared E. Wolf· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Doelle

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2 papers

Recent·Most cited

BiochemistrybioRxivJun 1, 2022

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

S. Bothe, P. Haenzelmann, S. Boehler…·C. Sotriffer

The paper uses biolayer interferometry to identify small molecule ligands targeting the SHP-motif binding site of p97, leading to the first structure of a small molecule complex with the N-domain of p97.

DOI 10.1038/s42004-022-00782-5

experimental assaydrug response / drug discovery

Cancer BiologybioRxivPreprintApr 12, 2021

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

A. Doelle, B. Adhikari, A. Kraemer…·S. Knapp

This study designs, synthesizes, and evaluates two series of WDR5 degraders, showing that linker length and nature affect degradation efficacy.

DOI 10.1101/2021.04.12.439490

experimental assaywet-lab / biochemical assay