Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders
A. Doelle, B. Adhikari, A. Kraemer, J. Weckesser, N. Berner, L.-M. Berger, M. Diebold, M. Szewczyk, D. Barsyte-Lovejoy, C. Arrowsmith, J. Gerbel, F. Loehr, V. Doetsch, M. Eilers, S. Heinzlmeir, , S. Knapp
This study designs, synthesizes, and evaluates two series of WDR5 degraders, showing that linker length and nature affect degradation efficacy.
bioRxiv · Apr 12, 2021 · PreprintCancer Biology