Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer
A. Ahmed, P. Charoentong, R. Klotz, S. Koehler, M. Suarez-Carmona, N. A. Valous, D. Ferber, M. Heikenwaelder, N. Giese, T. Hackert, F. Klupp, M. Schneider, T. Schmidt, C. Springfeld, Y. Tanriver, , N. Halama
This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.
bioRxiv · Mar 13, 2021 · PreprintCancer Biology