T. Schmidt

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

AI-assisted decoding of molecular signatures essential for NON-PHOTOTROPIC HYPOCOTYL3 condensation and function in phototropism

The paper uses AI-based protein structure prediction to identify a bipartite motif in NPH3 essential for its condensation and function in phototropism.

Unifying the analysis of bottom-up proteomics data with CHIMERYS

CHIMERYS deconvolves chimeric spectra in proteomic data, enabling unified analysis across DDA, DIA, and PRM experiments by accurately identifying and quantifying multiple peptides per spectrum.

Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and Paclitaxel.

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.

DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

This study shows that DTX3L ubiquitinates single-stranded DNA and RNA, expanding the known substrates of ubiquitination beyond proteins.

Plasmonic Enhancement of Protein Function

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

Single-Cell Stress Analysis in Tumoroids.

This paper introduces a method to measure cellular traction forces in 3D tumoroid cultures using elastic microparticles, revealing cellular stress ranges and interactions with the extracellular matrix.

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche

The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

This study identifies ABCB1 overexpression via locus amplification as a conserved mechanism of paclitaxel resistance in PDAC and shows that targeting ABCB1 can sensitize resistant cells to treatment.

Uncovering the Environmental Conditions Required for Phyllachora maydis Infection and Tar Spot Development on Corn in the United States for Use as Predictive Models for Future Epidemics

Cell-Cell Separation Device: measurement of intercellular detachment forces.

The paper introduces a microstructured device to measure intercellular detachment forces and external stresses in adherent cells.

IgG4 serum levels are not elevated in cases of Post-COVID syndrome

The paper compares IgG subtypes in Post-COVID patients and controls, finding no elevation in IgG4 but reduced IgG2, suggesting potential role of IgG2 in Post-COVID syndrome.

Hidden endosymbionts: A male-killer concealed by another endosymbiont and a nuclear suppressor

The paper identifies a male-killing Wolbachia strain in Drosophila pseudotakahashii, hidden by a cytoplasmic incompatibility Wolbachia and a nuclear suppressor, revealing complexities in endosymbiont detection and host interactions.

Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density

This study investigates how cell adhesion and density influence the hexanematic crossover in epithelial monolayers, showing its dependence on these factors.

Opposing diet, microbiome and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

Communication determines population-level fitness under cation stress by modulating the ratio of motile to sessile B. subtilis cells

The paper shows that motile B. subtilis cells are more susceptible to cation stress than sessile cells, and that population fitness under stress is influenced by communication via ComX-pheromone signaling.

Substrate rigidity modulates traction forces and stoichiometry of cell matrix adhesions.

The paper quantifies how substrate stiffness affects traction forces and molecular composition of cell-matrix adhesions using superresolution microscopy.

Effect of G4C2-Repeat Expansions on the Motion of Lysosomes Inside Neurites.

This study examines how G4C2 repeat expansions affect lysosome motion in neurites, finding reduced velocity and reach, and altered trafficking directionality.

Single cell micro-pillar-based characterization of endothelial and fibroblast cell mechanics

This study measures traction force profiles of endothelial and fibroblast cells using a micropillar-based assay, revealing differences in their mechanical properties.

Characterization of Cell-Induced Astigmatism in High-Resolution Imaging.

The paper characterizes cell-induced astigmatism in high-resolution imaging and shows that nuclear astigmatism can cause significant positional inaccuracies.

SARS-CoV-2 Neutralization in Commercial Lots of Plasma-derived Immunoglobulin

This study assesses SARS-CoV-2 neutralization in plasma-derived immunoglobulin (IVIG/SCIG) products and convalescent plasma, showing increasing neutralizing titers over time.

Impact of neurite alignment on organelle motion.

This study investigates how neurite alignment affects lysosome motion in PC12 cells, finding faster diffusive and super-diffusive movement in aligned neurites compared to random orientations.

Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue

The paper uses single-molecule microscopy to analyze H-Ras protein dynamics in zebrafish embryos, revealing cellular heterogeneity in diffusion rates.

Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia

This study examines genetic stability in Aedes aegypti populations after Wolbachia wMel introduction, finding genome-wide stability but some gene-level changes related to immune response and development.

The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

Light-triggered and phosphorylation-dependent 14-3-3 association with NONPHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism

This study shows that light-induced phosphorylation of NPH3 enables 14-3-3 binding, leading to NPH3 release from the plasma membrane and its function in phototropism.

Comparative repeat profiling of two closely related conifers (Larix decidua and Larix kaempferi) reveals high genome similarity with only one fast-evolving satellite DNA

The paper compares repeat profiles of two conifer species, finding high genome similarity with only one fast-evolving satellite DNA.

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.

IHR-PVS National Bridging Workshops, a tool to operationalize the collaboration between human and animal health while advancing sector-specific goals in countries

The paper describes the development of IHR-PVS National Bridging Workshops to enhance collaboration between human and animal health sectors through structured, outcome-oriented processes.