S. Koehler

Structure of fungal tRNA ligase with RNA reveals conserved substrate binding principles

The paper reports the crystal structure of fungal Trl1-LIG with a tRNA substrate, revealing conserved binding principles and RNA end specificity.

Skp1 proteins are structural components of the synaptonemal complex in C. elegans

This study identifies SKR-1 and SKR-2 as structural components of the synaptonemal complex in C. elegans, independent of their role in the SCF ubiquitin ligase complex.

Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes

Drosophila Filamin exhibits a mechano-protective role during nephrocyte injury via induction of hypertrophic growth

This study identifies Cheerio (dFilamin) as a mechano-protective factor in Drosophila nephrocytes, inducing hypertrophy to preserve filtration function during injury.

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.

High-throughput, low-cost and rapid DNA sequencing using surface-coating techniques

This paper introduces a surface-coating technique to improve DNA sequencing speed, cost, and throughput for genomic applications.

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Tumor invasion as non-equilibrium phase separation

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

Phylogeny of the stink bug tribe Chlorocorini (Heteroptera, Pentatomidae) based on DNA and morphological data: the evolution of key phenotypic traits

This study combines DNA and morphological data to reconstruct the phylogeny of the stink bug tribe Chlorocorini, revealing that the tribe is not monophyletic and many morphological traits are homoplastic.

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levels

This study shows that Par3A and Par3B regulate RhoA levels and podocyte architecture through interactions with Synaptopodin and CD2AP in mouse and Drosophila models.

Secondary origin, hybridization and sexual reproduction in a diploid-tetraploid contact zone of the facultative apomictic orchid Zygopetalum mackayi.

The paper investigates polyploid establishment in Zygopetalum mackayi by analyzing genetic diversity and structure across cytotypes, finding no evidence of reproductive interference and suggesting polyploidy, not apomixis, drives fitness.

The unjamming transition is distinct from the epithelial-to-mesenchymal transition.

This paper distinguishes the unjamming transition (UJT) from the epithelial-to-mesenchymal transition (EMT) by showing UJT enables collective epithelial migration without EMT features.

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

A compartmentalized signaling network mediates crossover control in meiosis

This paper identifies a family of RING finger proteins in C. elegans that form a signaling network regulating crossover control during meiosis.

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.