Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
S. Pelech, C. Gallagher, C. Sutter, L. Yue, J. Kerwin, A. Bhargava, E. Iorns, R. Tsui, A. Denis, N. Perfito, T. M. Errington
This replication study confirms some findings of the original study on RAF inhibitors and their effects on MAPK pathway activation but reports discrepancies in key experiments.
bioRxiv · Nov 30, 2021 · PreprintCancer Biology