Author

A. Denis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. Bhargava· 1 shared A. Brewster· 1 shared A. C. Pearce· 1 shared A. Dossang· 1 shared a. guihot· 1 shared A. M. Jagger· 1 shared A. Olszewski· 1 shared A. Ordonez· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bhargava

Author profile →

3 papers

Recent·Most cited

Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

S. Pelech, C. Gallagher, C. Sutter, L. Yue, J. Kerwin, A. Bhargava, E. Iorns, R. Tsui, A. Denis, N. Perfito, T. M. Errington

This replication study confirms some findings of the original study on RAF inhibitors and their effects on MAPK pathway activation but reports discrepancies in key experiments.

bioRxiv · Nov 30, 2021 · PreprintCancer Biology

hACE2 peptide mimics block SARS-CoV-2 Pulmonary Cells Infection

P. Karoyan, V. Vieillard, E. Odile, A. Denis, a. guihot, c. e. luyt, L. Gomes-Morales, P. Grondin, O. Lequin

The paper designs peptide mimics of hACE2 that block SARS-CoV-2 infection in pulmonary cells with nanomolar inhibitory concentrations.

bioRxiv · Aug 24, 2020 · PreprintPharmacology & Toxicology

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

D. Lomas, J. A. Irving, C. Arico-Muendel, S. Belyanskaya, A. Brewster, M. J. B. Brown, C.-w. Chung, H. Dave, A. Denis, N. Dodic, A. Dossang, P. Eddershaw, D. Klimaszewska, I. Haq, D. Holmes, , A. C. Pearce

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

bioRxiv · Jul 26, 2020Pharmacology & Toxicology