Author

C. Trefois

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Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Assay:metabolomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

C. A. F. Kuate· 1 shared M. Besancon· 1 shared M. Kratochvil· 1 shared O. Ebenhoeh· 1 shared S. E. Wilken· 1 shared W. Gu· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBioengineering

C. A. F. Kuate

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1 paper

Recent·Most cited

Interrogating the effect of enzyme kinetics on metabolism using differentiable constraint-based models

S. E. Wilken, M. Besancon, M. Kratochvil, C. A. F. Kuate, C. Trefois, W. Gu, O. Ebenhoeh

This paper differentiates optimal solutions of constraint-based metabolic models to calculate sensitivities of reaction fluxes and enzyme concentrations to turnover numbers, improving parameter estimation and connecting to metabolic control analysis.

bioRxiv · Jul 11, 2022Bioengineering