W. Gu

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Five-layered robot (F-robot) based on functionally graded multilayer foam antiviral low-carbon (F-MAX) system for Pathogenic Microorganism Elimination

The paper introduces an air filtration system using a multilayer composite with antiviral and antibacterial properties, suitable for both commercial and residential environments.

Evaluation of Deep Neural Network Models for Instance Segmentation of Lumbar Spine MRI

This paper evaluates 15 DNN models for instance segmentation of lumbar spine MRI using a new synthetic dataset and two metrics.

Single cell sequencing of pig lungs reveals immune responses underlying influenza infection and oseltamivir therapy

This study uses single-cell sequencing to analyze pig lung immune responses to influenza infection and oseltamivir treatment, identifying conserved and species-specific features.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

Cyclic di-GMP interact with putrescine via a PilZ domain receptor YcgR

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

Lower shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure

This study shows that preventing p53 acetylation improves coronary microvascular dysfunction and prevents heart failure in a mouse model of pressure overload.

Restoring glucose homeostasis with stomach-derived human insulin-secreting organoids

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

Interrogating the effect of enzyme kinetics on metabolism using differentiable constraint-based models

This paper differentiates optimal solutions of constraint-based metabolic models to calculate sensitivities of reaction fluxes and enzyme concentrations to turnover numbers, improving parameter estimation and connecting to metabolic control analysis.

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

Matrix viscoelasticity controls spatio-temporal tissue organization

This study shows how matrix viscoelasticity influences tissue organization by causing symmetry breaking and branching in epithelial cell aggregates.

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

Recurrent allopolyploidization events diversify eco-physiological traits in marsh orchids

This study shows that recurrent allopolyploidy in marsh orchids leads to distinct eco-physiological traits adapted to different environments.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening

The paper identifies a transient P-pocket in HIV-1 reverse transcriptase during DNA sliding and demonstrates fragment screening to target this pocket for inhibitor development.

The middle lipin (M-Lip) domain is a new dimeric protein fold that binds membranes

The paper identifies the M-Lip domain as a novel dimeric protein fold that binds membranes and is essential for lipin function.

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

The paper determines the crystal structure of the Drosophila SARM1 ARM domain using MIRAS phasing, revealing insights into its regulation and activation mechanism.

Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stage

The paper shows that bacterial DNA recombination increases tRNA levels early in antibiotic stress, aiding resistance before efflux pumps or mutations.

Effect of the BMPR-II-SMAD3/MRTF complex on proliferation and migration of ASMCs and the mechanism in asthma.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

Enhancement of nitrous oxide emissions in soil microbial consortia via copper competition between proteobacterial methanotrophs and denitrifiers

This study shows that copper competition between methanotrophs and denitrifiers in rice paddy soils increases nitrous oxide emissions through methanobactin-mediated copper sequestration.

Predicting the Viability of Beta-Lactamase: How Folding and Binding Free Energies Correlate with Beta-Lactamase Fitness

This paper evaluates how well thermodynamic folding and binding free energies predict the fitness of beta-lactamase mutants using experimental data and computational models.

The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

Expanding the chemical space of synthetic cyclic peptides using a promiscuous macrocyclase from prenylagaramide biosynthesis

This study identifies promiscuous macrocyclases that enable the synthesis of diverse cyclic peptides without requiring thiazole/thiazoline termini.

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

Effects of the anesthetic MS-222 on silver pomfret (Pampus argenteus) juveniles under aquaculture treatment stresses

This paper determines the optimal dose and duration of MS-222 anesthesia for silver pomfret juveniles under aquaculture stress and shows it reduces oxidative damage and stress response.