Author

S. E. Wilken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:E. coli· 1 Assay:metabolomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

O. Ebenhoeh· 2 shared C. A. F. Kuate· 1 shared C. Trefois· 1 shared M. Besancon· 1 shared M. Kratochvil· 1 shared N. P. Saadat· 1 shared V. V. Frazao· 1 shared W. Gu· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersBioengineering

O. Ebenhoeh

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2 papers

Recent·Most cited

BioengineeringbioRxivJul 11, 2022

Interrogating the effect of enzyme kinetics on metabolism using differentiable constraint-based models

S. E. Wilken, M. Besancon, M. Kratochvil…·O. Ebenhoeh

This paper differentiates optimal solutions of constraint-based metabolic models to calculate sensitivities of reaction fluxes and enzyme concentrations to turnover numbers, improving parameter estimation and connecting to metabolic control analysis.

DOI 10.1016/j.ymben.2022.09.002

E. colimetabolomics

𝕏 PostBluesky

BioengineeringbioRxivApr 16, 2021

The view of microbes as energy converters illustrates the trade-off between growth rate and yield

S. E. Wilken, V. V. Frazao, N. P. Saadat, O. Ebenhoeh

This paper reviews black box models and thermodynamic integration in genome-scale metabolic models to understand the trade-off between microbial growth rate and yield.

DOI 10.1042/bst20200977

statistical model

𝕏 PostBluesky