BiochemistrybioRxivPreprint
Regioselective control of biocatalytic C-H activation and halogenation
E. N. Kissman, M. E. Neugebauer, K. H. Sumida…·M. C. Y. Chang
The paper investigates the selectivity mechanisms of halogenases HalB and HalD, revealing how substrate-lid positioning enables regioselective chlorination of lysine and ornithine.
DOI 10.1101/2022.08.04.502814