Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
C. Tripodo, B. Bassani, E. Jachetti, V. Cancila, C. Chiodoni, P. Portararo, L. Botti, C. Vaenti, M. Perrone, M. Ponzoni, P. Comoli, A. Curti, M. P. Colombo, S. Sangaletti
This study demonstrates that neutrophil extracellular traps (NETs) loaded with mutant NPMc+ can be used as a vaccine to treat NPMc-driven myeloproliferation by inducing CD8+ T cell responses and reducing leukemic expansion.
bioRxiv · May 19, 2021Immunology