Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection
C. W. Ang, B. M. Lee, C. J. Jackson, Y. Wang, S. G. Franzblau, A. F. Francisco, J. M. Kelly, P. V. Bernhardt, L. Tan, N. P. West, M. L. Sykes, A. O. Hinton, R. Bolisetti, V. M. Avery, M. A. Cooper, M. Blaskovich
This paper evaluates nitroimidazopyrazinone derivatives for antitubercular and antiparasitic activity, showing selectivity against M. tuberculosis and efficacy against T. cruzi in mouse models.
Journal of Medicinal Chemistry · Oct 13, 2022Peer-reviewedPharmacology & Toxicology