Author

M. Blaskovich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

K. Tsaneva-Atanasova· 2 shared S. Pagliara· 2 shared A. Campey· 1 shared A. F. Francisco· 1 shared A. Farbos· 1 shared A. Jeffries· 1 shared A. O. Hinton· 1 shared B. M. Lee· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

K. Tsaneva-Atanasova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phage-induced efflux down-regulation boosts antibiotic efficacy

S. Kraus, U. Lapinska, K. Chawla, E. Baker, E. Attrill, P. ONeill, A. Farbos, A. Jeffries, E. Galyov, S. Korbsrisate, K. Barnes, S. Harding, K. Tsaneva-Atanasova, M. Blaskovich, S. Pagliara

This study shows that phage presence reduces antibiotic efflux in bacteria, enhancing antibiotic efficacy and enabling lower concentrations for treatment.

bioRxiv · Sep 21, 2023Microbiology

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

C. W. Ang, B. M. Lee, C. J. Jackson, Y. Wang, S. G. Franzblau, A. F. Francisco, J. M. Kelly, P. V. Bernhardt, L. Tan, N. P. West, M. L. Sykes, A. O. Hinton, R. Bolisetti, V. M. Avery, M. A. Cooper, M. Blaskovich

This paper evaluates nitroimidazopyrazinone derivatives for antitubercular and antiparasitic activity, showing selectivity against M. tuberculosis and efficacy against T. cruzi in mouse models.

Journal of Medicinal Chemistry · Oct 13, 2022Peer-reviewedPharmacology & Toxicology

Fast bacterial growth reduces antibiotic accumulation and efficacy

U. Łapinska, M. Voliotis, K. K. Lee, A. Campey, R. Stone, W. Phetsang, B. Zhang, K. Tsaneva-Atanasova, M. Blaskovich, S. Pagliara

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

bioRxiv · Oct 18, 2021Microbiology

Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing Klebsiella pneumoniae ST258 Clinical Isolate Compared to Polymyxins

M. Pitt, M. D. Cao, M. Butler, S. Ramu, D. Ganesamoorthy, M. Blaskovich, L. Coin, M. Cooper

This study compares resistance development in XDR Klebsiella pneumoniae ST258 exposed to polymyxins and octapeptin C4, finding OctC4 induces less resistance and novel mutations.

bioRxiv · Apr 28, 2018Microbiology