Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint
E. Masle-Farquhar, T. J. Peters, L. A. Miosge, I. A. Parish, C. Weigel, C. C. Oakes, J. H. Reed, C. Goodnow
This study identifies EGR2 and EGR3 as critical transcription factors that suppress CD21low and B1 B cell accumulation by repressing plasma cell differentiation and follicular germinal center formation.
bioRxiv · Jul 1, 2021Immunology