Author

J. H. Reed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Assay:flow cytometry· 1

Frequent Co-Authors

C. C. Goodnow· 3 shared E. Masle-Farquhar· 3 shared T. J. Peters· 3 shared D. Suan· 2 shared G. Uzel· 2 shared I. Chua· 2 shared J. W. Leiding· 2 shared K. Heiskanen· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

C. C. Goodnow

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 11, 2022

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

E. Masle-Farquhar, K. J. L. Jackson, T. J. Peters…·C. C. Goodnow

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

DOI 10.1101/2022.02.11.480027

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 20, 2021

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

E. Masle-Farquhar, T. J. Peters, K. J. Jackson…·C. C. Goodnow

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

DOI 10.1101/2021.12.20.473595

humanmouse

𝕏 PostBluesky

ImmunologybioRxivJul 1, 2021

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

E. Masle-Farquhar, T. J. Peters, L. A. Miosge…·C. Goodnow

This study identifies EGR2 and EGR3 as critical transcription factors that suppress CD21low and B1 B cell accumulation by repressing plasma cell differentiation and follicular germinal center formation.

DOI 10.1016/j.celrep.2021.110259

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 29, 2021

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews…·A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

DOI 10.1101/2021.01.29.428877

mouseexperimental assay

𝕏 PostBluesky