E. Masle-Farquhar

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

This study identifies EGR2 and EGR3 as critical transcription factors that suppress CD21low and B1 B cell accumulation by repressing plasma cell differentiation and follicular germinal center formation.

This study shows that loss-of-function mutations in Fbxo10 do not increase BCL2 or B lymphocyte numbers in mice, suggesting redundant regulation of BCL2 by other ubiquitin ligases.