Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
C.-C. Chou, R. Vest, M. A. Prado, J. Wilson-Grady, J. A. Paulo, Y. Shibuya, P. Moran-Losada, T.-T. Lee, J. Luo, S. P. Gygi, J. W. Kelly, D. Finley, M. Wernig, T. Wyss-Coray, J. Frydman
This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.
bioRxiv · Mar 27, 2023Cell Biology