Cell BiologybioRxiv
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
C.-C. Chou, R. Vest, M. A. Prado…·J. Frydman
This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.
DOI 10.1038/s41556-025-01623-y