J. Luo

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Piezo1 is a mechanosensor of soft matrix viscoelasticity

The paper shows Piezo1 senses viscoelasticity in soft ECMs and identifies transcriptomic changes in MSCs in response to matrix properties and Piezo1 activity.

Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

This study investigates how single-atom mutations in the recognition lobe of GeoCas9 affect its structure, dynamics, and guide RNA interactions without altering its functional specificity.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation

This study identifies how the bacterial effector RipE1 stabilizes by hijacking plant ubiquitin proteases and phosphorylation, avoiding degradation and promoting bacterial survival.

Key link between iron and the size structure of three main mesoplanktonic groups (Crustaceans, Rhizarians, and colonial N2-fixers) in the Upper Ocean

The paper links iron availability to the size structure of three mesoplankton groups in the upper ocean, showing iron's role in shaping their biogeography and ecosystem services.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions

This study investigates how salt concentration affects the phase separation and aggregation of alpha-synuclein, revealing distinct salt dependencies and dynamic transitions between assembly states.

Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.

This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.

Dispersal and evolution of the invasive snail Pomacea canaliculata, an intermediate host of Angiostrongylus cantonensis: A field study around its initial introduction site in China

This study investigates the spatial distribution, phenotypic variation, and dispersal patterns of the invasive snail Pomacea canaliculata in China, revealing human-mediated evolution and potential complexities in parasite transmission.

Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.

The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

Host signature as major driver of root and rhizosphere core microbiomes that differently affect plant functional traits

The paper identifies plant traits as the main driver of core microbiomes in different root compartments and shows their distinct impacts on plant metal accumulation and growth.

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

miRNA and mRNA Signatures in Human Acute Kidney Injury Tissue

This study identifies miRNA and mRNA signatures in human AKI tissue, revealing their roles in inflammation, immune activation, and epithelial-to-mesenchymal transition, and highlights the importance of using appropriate reference controls.

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes

This study identifies EZH2 as a dependency in NUT carcinoma, showing that combining EZH2 and BET inhibitors synergistically blocks tumor growth and prolongs survival.

A microfluidic strategy to capture antigen-specific high affinity B cells

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease

This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.

Variation of wine preference amongst consumers is influenced by the composition of salivary proteins

The study shows that differences in salivary protein composition between Western and Chinese wine tasters influence their perception and preference for wine flavors.

Whole mouse body histology using standard IgG antibodies

The paper introduces wildDISCO, a method to perform whole-body histology in mice using standard IgG antibodies, revealing interactions between nervous, immune, and lymphatic systems.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

Insights into the Microbial Weathering of Chinese Wooden Ancestral Halls in Guangdong Province

The paper analyzes microbial diversity in ancestral halls in Guangdong Province, identifying cellulose- and lignin-degrading microbes and evaluating biocides for wood preservation.