GeneticsbioRxivPreprint
KAT6A mutations drive transcriptional dysregulation of cell cycle and Autism risk genes in an Arboleda-Tham Syndrome cerebral organoid model
Aileen A. Nava, Connor T. Jops, Celine K. Vuong…·Valerie A. Arboleda
This study shows KAT6A mutations cause transcriptional dysregulation of cell cycle and autism risk genes in cerebral organoids, leading to delayed neural differentiation and altered gene expression patterns.