PhysiologybioRxiv
A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Brennan J Wadsworth, Marina Leiwe, Eleanor A Minogue…·Randall S Johnson
This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.
DOI 10.7554/elife.92707.2