A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor
Shehani Kahawatte, Amanda C. Macke, Carter St. Clair, Ruxandra I. Dima
This study uses molecular dynamics and machine learning to analyze how the R591S mutation in spastin affects its dynamics and allostery, leading to impaired microtubule severing and HSP-related dysfunction.
Biochemistry · Feb 26, 2025Peer-reviewedBiophysics