Author
Amanda C. Macke
University of CincinnatiORCID 0000-0001-8927-0389Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 19 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- BiophysicsBiochemistryPeer-reviewed
A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor
Shehani Kahawatte, Amanda C. Macke, Carter St. Clair, Ruxandra I. Dima
This study uses molecular dynamics and machine learning to analyze how the R591S mutation in spastin affects its dynamics and allostery, leading to impaired microtubule severing and HSP-related dysfunction.
4 citations - BiophysicsJournal of Chemical Information and ModelingPeer-reviewed
Searching for Structure: Characterizing the Protein Conformational Landscape with Clustering-based Algorithms
Amanda C. Macke, Jacob E. Stump, Maria S. Kelly…·Ruxandra I. Dima
This paper introduces StELa, a clustering method that identifies protein conformational minima more effectively than existing methods like GROMOS and CATS.
4 citations