Author

Chen Shen

Case Western Reserve University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Anne-Claire KrogeriD· 1 shared Aurélien J. F. DugourdiD· 1 shared Blerta Shtylla· 1 shared Dénes TüreiiD· 1 shared Diego MañanesiD· 1 shared Drew Nager· 1 shared Jia Li· 1 shared John D. Lapek· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperBioinformatics

Anne-Claire KrogerORCID

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4 papers

Recent·Most cited

Therapeutic Potential of iPSC-Derived TH+FOXA2+ Neuronal Extracellular Vesicles in Parkinson's Disease Revealed by Organoid and Rodent Models

Zongjun Liu, Zhen Qi, Xiaowen Li, Chen Shen, Lan Yang, Yandan Liu, Mingqian Huang, Lina Xing, Yan Chen

This study evaluates the therapeutic potential of iPSC-derived TH+FOXA2+ neuronal extracellular vesicles in Parkinson's disease models, showing neuroprotection and safety.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Exploring the potential value of aloe active components in inhibiting non-small cell lung cancer through network pharmacology

Chen Shen, Mengxi Zhu, Jia Li, Yi Wang, Shu-Feng Zhou

This study uses network pharmacology to identify Aloe vera compounds that target NSCLC through multiple pathways and proteins, suggesting potential for new anticancer therapies.

Journal of Biomedicine and Big Data · Dec 10, 2025Peer-reviewedBioinformatics

Endoplasmic reticulum stress protein GRP78 for ketamine's antidepressant effects

Wanpeng Cui, Chen Shen, Wen‐Cheng Xiong, Lin Mei

This study identifies GRP78 as critical for ketamine's antidepressant effects by enhancing glutamatergic transmission in the prefrontal cortex.

bioRxiv · Feb 22, 2025 · PreprintNeuroscience

Modeling causal signal propagation in multi-omic factor space with COSMOS

Aurélien J. F. Dugourd, Pascal Lafrenz, Diego Mañanes, Víctor Patón, Robin Fallegger, Anne-Claire Kroger, Dénes Türei, Yunfan Bai, Yuxin Li, Michael Trogdon, Drew Nager, Shibing Deng, Chen Shen, John D. Lapek, Blerta Shtylla, Julio Sáez-Rodríguez

The paper introduces COSMOS+ to integrate mechanistic prior knowledge with multi-omics data analysis to generate mechanistic hypotheses about disease resistance mechanisms.

bioRxiv · Jul 15, 2024 · PreprintBioinformatics