Epigenetic reprogramming induced by Acetyl-CoA and SAM depletion is an evolutionarily-ancient path to malignant growth
Zhe Chen, Xiaomeng Zhang, Mingxi Deng, Chongyang Li, Thi Thuy Nguyen, Min Liu, Kun Dou, Toyotaka Ishibashi, Jiguang Wang, Yan Yan
This study identifies common metabolic and epigenetic changes in fly and human tumors, showing that metabolite depletion drives tumorigenesis across species.
bioRxiv · Jan 1, 2025Developmental Biology